Several months after Mikey Palmice's execution and Livia's hospitalization, things are back to business once again. Tony begins to self-medicate and has not been receiving regular therapy sessions. Melfi begins conducting therapy sessions at a motel after being warned that her office is no longer safe. Christopher hires another man to take his Stock Broker's licensing exam. Uncle Junior is in jail. Carmela continues to play the role of "housewife". Livia begins receiving physical therapy. Raymond continues to bring in the money for Tony as does Paulie and Silvio who indulge in designer shoes and Bada Bing strippers. Tony continues to see his Russian goomara Irina and hides that he was out all night by doing a load of laundry. He then sneaks into bed and falls asleep. The following morning, as Tony goes to fetch the paper he sees a Buick Riviera sitting in his driveway. Tony starts to run away, thinking this may be a hit, only to have Pussy to emerge. Tony yells, "You've been gone all these months...and this is how you come back to me!?"

Tony and Pussy then go down to Tony's basement where they discuss why Pussy was absent all those months. Pussy tries to explain that he was in Puerto Rico because of his back and he did not want to tell his wife since he met a girl while he was there and that he no longer felt safe in New Jersey because of the impressions previously caused by Tony and his crew. Tony still does not trust Pussy and as he goes to hug him he pats him down. Pussy becomes offended at this but Tony continues to hug him for real this time. At the Bada Bing, the associates welcome Pussy and Silvio entertains the group with impressions from The Godfather.

The following day, Christopher is made the FTC compliance officer (actually the "head") of an investment firm and is pressuring people to push a new worthless stock, Webistics. When Christopher takes a "meeting" down the shore (with Adriana), he places Matt Bevilaqua, a fellow stockbroker in charge. While Matt is doing his rounds with friend Sean to make sure people are advising the purchase of Webistics, they discover one broker is not doing as he is told, and is providing general investment advice based on the needs of the customer. They proceed to pour hot coffee on him and beat him. The former manager tells them to break it up but is threatened by Matt to go back to his office. The following day, Tony receives a phone call from the firm stating that Christopher is not doing his job and that two people left because of an "incident". Tony tells Christopher to be careful and to make himself available at the firm instead of being a "no-show".

Tony then receives a phone call from Carmela who informs him that his long lost sister, Janice has resurfaced and is looking for a place to stay. Tony says, "You gotta be shitting me?" He invites Janice to stay but knows that when she leaves he will be "$5000 lighter". Tony then suggests to Carmela that they have a big family reunion with Tony's other older sister Barbara and all of the children. He makes it clear that Livia is not to be invited.

While driving, Tony has a panic attack and runs off the road. He is not hurt as his airbag deployed after he ran into a barricade. He meets with another psychiatrist to discuss his panic attacks and his mother. The psychiatrist tells Tony that he recognizes him and has seen Analyze This, and informs him that he is not taking new clients at this time.

Tony then talks with Janice about Livia and that he never wants her spoken of in the Soprano house again. Janice understands what is going on but will continue to see Livia and possibly vacate her house. Tony tells her that it is not possible since Tony is selling the house. Janice tries to convince him not to but Tony has his mind made up. Tony and Carmela are soon asked to the house by a realtor who informs them that Livia's house was vandalized. Carmela then asks when he is getting back into therapy and tells Tony that her parents will be coming to the party as well. It is revealed that Carmela's parents avoided gatherings where Livia would be present, due to comments Livia had made to them.

At the party, everyone seems to have a good time except for Tony who is angered about his mother and Carmela asks the question once again "When are you getting back into therapy?" Tony states that he does not know but that he has been self-medicating. Carmela then suggests that he go have a good time with his friends and family and not worry about Livia. Tony does so and continues to joke around with Pussy. Meanwhile, Janice and Barbara are talking about Tony's handling of the situation. Janice thinks that no one is going to get their fair share from the house but Barbara believes that Tony is handling the situation very well and that he will give them both their fair share.

Tony orders a hit on Philly "Spoons" Parisi, an active soldier in the Junior Soprano crew who has been spreading rumours regarding Tony attempting to suffocate his own mother with a pillow. Tony asks Gigi Cestone to do the hit so that it will not look obvious. When Gigi gets out of Philly what he knows, he shoots him in the head. When everything is once again safe, Tony calls Melfi from a payphone to tell her she can go home. The following morning at a diner, Tony tries to apologize to Dr. Melfi who is extremely upset that she could not help another patient who committed suicide. Tony feels bad but tries to ask her if he can come back, or for a referral. She tells him to get out of her life and not to expect a referral, and he leaves the diner. Tony then goes home to have lunch with Carmela who is surprised that he is home early.